Synthesis and biological activities of meribendan and related heterocyclic benzimidazolo-pyridazinones

…, I Lues, H Prücher, HJ Schliep, H Wurziger

Index: Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140

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Citation Number: 54

Abstract

Abstract The synthesis of new heterocyclic benzimidazolo-pyridazinones is described. The new compounds were evaluated as inotropic agents with 'calcium-sensitizing'effects. 5- Methyl-6-[2-(3-pyrazolyl)-5-benzimidazolyl]-2, 3, 4, 5-tetrahydro-pyridazin-3-one hydrochloride (meribendan) turned out to be the most interesting compound and was chosen for development as a positive inotrope.