Tetrahedron: Asymmetry

Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations

JD Hull, F Scheinmann, NJ Turner

Index: Hull, Jonathan D.; Scheinmann, Feodor; Turner, Nicholas J. Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 567 - 576

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Citation Number: 21

Abstract

Racemic methadone 1 continues to be used as a maintenance drug in the treatment of heroin 2 addiction. 1 Methadone has also been used in the treatment of severe pain symptoms. 2., and The value of using racemic methadone orally is that it also helps to combat the spread of HIV by reducing injection of heroin. 1 Under medical supervision, the addict can lead a more stable life but there is a temptation to remain on racemic methadone to avoid the withdrawal ...