Studies of the inactivation of general acyl-CoA dehydrogenase by racemic (methylenecyclopropane) acetyl-CoA-new evidence suggesting a radical mechanism of this …

ND Lenn, Y Shih, MT Stankovich…

Index: Lenn, Nancy D.; Shih, Younan; Stankovich, Marian T.; Liu, Hung-wen Journal of the American Chemical Society, 1989 , vol. 111, # 8 p. 3065 - 3067

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Citation Number: 36

Abstract

4 2 attempts to solve this long disputed problem have involved the use of spectroscopic reaction kinetic techniques coupled with the use of deuterated substrates or deazaflavin ana1ogues. lM Although the results of these experiments have been interpreted to support the hydride-transfer mechanism (eq I), it is not yet certain whether substitution of deazaflavin for flavin induces a change in the enzyme mechanism.