Organic letters

Selective reduction of carboxylic acids to aldehydes catalyzed by b (c6f5) 3

D Bézier, S Park, M Brookhart

Index: Bezier, David; Park, Sehoon; Brookhart, Maurice Organic Letters, 2013 , vol. 15, # 3 p. 496 - 499

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Citation Number: 31

Abstract

B (C6F5) 3 efficiently catalyzes hydrosilylation of aliphatic and aromatic carboxylic acids to produce disilyl acetals under mild conditions. Catalyst loadings can be as low as 0.05 mol%, and bulky tertiary silanes are favored to give selectively the acetals. Acidic workup of the disilyl acetals results in the formation of aldehydes in good to excellent yields.