Tetrahedron Letters

O, O-Diethyl dithiophosphoric acid mediated direct synthesis of thioamides from aldehydes and ketones

AK Yadav, VP Srivastava, LDS Yadav

Index: Yadav, Arvind K.; Srivastava, Vishnu P.; Yadav, Lal Dhar S. Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7113 - 7116

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Citation Number: 11

Abstract

A general and convenient method for a one-pot conversion of aldehydes and ketones into thioamides has been developed. The protocol involves oximation of aldehydes and ketones followed by deoxygenative thioamidation of oximes with O, O-diethyl dithiophosphoric acid which acts as an acid as well a source of sulfur. The method is operationally simple, high yielding, and also applicable to the conversion of amides and nitriles into the ...

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