Thioacetanilide

Modify Date: 2024-01-03 21:57:19

Thioacetanilide Structure
Thioacetanilide structure
 Common Name Thioacetanilide
CAS Number 637-53-6 Molecular Weight 151.22900
Density 1.16g/cm3 Boiling Point 147 °C / 1mmHg
Molecular Formula C8H9NS Melting Point 76-79 °C(lit.)
MSDS Chinese USA Flash Point 89.95ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Thioacetanilide


Thioacetanilide, purinylthioacetanilides derivative is being researched as a potent HIV-1 NNRTI.

 Names

Name Thioacetanilide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.16g/cm3
Boiling Point 147 °C / 1mmHg
Melting Point 76-79 °C(lit.)
Molecular Formula C8H9NS
Molecular Weight 151.22900
Flash Point 89.95ºC
Exact Mass 151.04600
PSA 44.12000
LogP 2.51880
Index of Refraction 1.654

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE7350000
CHEMICAL NAME :
Acetanilide, thio-
CAS REGISTRY NUMBER :
637-53-6
BEILSTEIN REFERENCE NO. :
2205727
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C8-H9-N-S
MOLECULAR WEIGHT :
151.24
WISWESSER LINE NOTATION :
SUY1&MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2635 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2625 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1775 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1820 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - changes in brain weight Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H312 + H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases R20/21
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AE7350000
HS Code 2930909090

 Synthetic Route

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles10

More Articles
The metabolism of thioacetanilide in the rat.

Xenobiotica 13(8) , 475-82, (1983)

The metabolism and acute toxicity of thioacetanilide was studied in the rat. Following intragastric dosage (100 mg/kg), over 90% dose was excreted in urine, predominantly as conjugated metabolites: le...

1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.

Bioorg. Med. Chem. 17(17) , 6374-9, (2009)

The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel structures of increased potency. Based on the bioisosteric principle, n...

Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Bioorg. Med. Chem. 17(16) , 5775-81, (2009)

A series of 2-(1-aryl-1H-imidazol-2-ylthio)acetamide [imidazole thioacetanilide (ITA)] derivatives were synthesized and evaluated as potent inhibitors of human immunodeficiency virus type-1 (HIV-1). A...

 Synonyms

MFCD00004942
N-phenylethanethioamide
EINECS 211-288-4
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