Thioacetanilide

Modify Date: 2024-01-03 21:57:19

Thioacetanilide structure	Common Name	Thioacetanilide
	CAS Number	637-53-6	Molecular Weight	151.22900
	Density	1.16g/cm3	Boiling Point	147 °C / 1mmHg
	Molecular Formula	C₈H₉NS	Melting Point	76-79 °C(lit.)
	MSDS	Chinese USA	Flash Point	89.95ºC
	Symbol	GHS07	Signal Word	Warning

Use of Thioacetanilide

Thioacetanilide, purinylthioacetanilides derivative is being researched as a potent HIV-1 NNRTI.

Name	Thioacetanilide
Synonym	More Synonyms

Density	1.16g/cm3
Boiling Point	147 °C / 1mmHg
Melting Point	76-79 °C(lit.)
Molecular Formula	C₈H₉NS
Molecular Weight	151.22900
Flash Point	89.95ºC
Exact Mass	151.04600
PSA	44.12000
LogP	2.51880
Index of Refraction	1.654

Thioacetanilide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE7350000

CHEMICAL NAME :: Acetanilide, thio-

CAS REGISTRY NUMBER :: 637-53-6

BEILSTEIN REFERENCE NO. :: 2205727

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H9-N-S

MOLECULAR WEIGHT :: 151.24

WISWESSER LINE NOTATION :: SUY1&MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2635 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2625 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1775 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg/26W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(2),72,1986

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H312 + H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R20/21
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AE7350000
HS Code	2930909090

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

The metabolism of thioacetanilide in the rat.

Xenobiotica 13(8) , 475-82, (1983)

The metabolism and acute toxicity of thioacetanilide was studied in the rat. Following intragastric dosage (100 mg/kg), over 90% dose was excreted in urine, predominantly as conjugated metabolites: le...

1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.

Bioorg. Med. Chem. 17(17) , 6374-9, (2009)

The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) offers the possibility of generating novel structures of increased potency. Based on the bioisosteric principle, n...

Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Bioorg. Med. Chem. 17(16) , 5775-81, (2009)

A series of 2-(1-aryl-1H-imidazol-2-ylthio)acetamide [imidazole thioacetanilide (ITA)] derivatives were synthesized and evaluated as potent inhibitors of human immunodeficiency virus type-1 (HIV-1). A...

MFCD00004942

N-phenylethanethioamide

EINECS 211-288-4