RSC Advances

Lithium tert-butoxide mediated α-alkylation of ketones with primary alcohols under transition-metal-free conditions

YF Liang, XF Zhou, SY Tang, YB Huang, YS Feng…

Index: Liang, Yu-Feng; Zhou, Xin-Feng; Tang, Shi-Ya; Huang, Yao-Bing; Feng, Yi-Si; Xu, Hua-Jian RSC Advances, 2013 , vol. 3, # 21 p. 7739 - 7742

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Citation Number: 11

Abstract

Carbon–carbon bond forming reactions are of fundamental importance in synthetic organic chemistry. The α-alkylation of ketones with electrophiles such as alkyl halides is an important tool for the construction of C–C bonds. 1 In recent years, alcohols have attracted increasing attention as electrophilic alkylating agents because they do not generate any side products other than water in the reaction. 2 In this context, several groups have reported the use of transition ...

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