Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase

…, M Jones, KJ Milliner, KK Rana, JG Ward

Index: Young, Rodney C.; Jones, Martin; Milliner, Kevin J.; Rana, Kishore K.; Ward, John G. Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2073 - 2080

Full Text: HTML

Citation Number: 52

Abstract

The possibility of deriving a potent, cell-penetrating inhibitor of human erythrocyte PI 4- kinase, competitive with respect to ATP, has been investigated in a series of purine derivatives and analogues. The purine nucleus is not essential for binding to the ATP site but offen the advantage of synthetic accessibility to its derivatives. The optimum substitution pattern in purine was found to be an electron-releasing substituent in the 6-position (eg ...