Methyl Orthocarboxylates as Methylating Agents of Heterocycles

YL Janin, C Huel, G Flad, S Thirot

Index: Janin, Yves L.; Huel, Christiane; Flad, Genevieve; Thirot, Sylvie European Journal of Organic Chemistry, 2002 , # 11 p. 1763 - 1769

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Citation Number: 3

Abstract

Abstract Methylation reactions occurring between trimethyl orthocarboxylates or N, N- dimethylcarboxamide dimethyl acetals and various hydroxylated heterocycles, involving a lactam-lactim tautomeric equilibrium, were investigated as an alternative to classic methylation methods. The corresponding O-methylated or N-methylated compounds were isolated in a number of instances and the reaction's regioselectivity was shown to ...