2-Thiouracil

Modify Date: 2024-01-02 17:29:18

2-Thiouracil structure	Common Name	2-Thiouracil
	CAS Number	141-90-2	Molecular Weight	128.152
	Density	1.5±0.1 g/cm3	Boiling Point	337.2ºC at 760mmHg
	Molecular Formula	C₄H₄N₂OS	Melting Point	>300 °C(lit.)
	MSDS	Chinese USA	Flash Point	157.7ºC
	Symbol	GHS08	Signal Word	Warning

Use of 2-Thiouracil

2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent. Target: Others2-Thiouracil is an established antithyroid drug and an extensively investigated agent for the early detection and targeting of metastatic melanotic melanoma. In addition, 2-Thiouracil is also a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerization. Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure. Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase [1-3].

Name	thiouracil
Synonym	More Synonyms

Description	2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent. Target: Others2-Thiouracil is an established antithyroid drug and an extensively investigated agent for the early detection and targeting of metastatic melanotic melanoma. In addition, 2-Thiouracil is also a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerization. Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure. Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase [1-3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Endocrinology
References	[1]. Palumbo, A., M. d'Ischia, and F.A. Cioffi, 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12. [2]. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201. [3]. Nagasaka, A. and H. Hidaka, Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J Clin Endocrinol Metab, 1976. 43(1): p. 152-8.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Endocrinology

References

[1]. Palumbo, A., M. d'Ischia, and F.A. Cioffi, 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12.

[2]. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201.

[3]. Nagasaka, A. and H. Hidaka, Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J Clin Endocrinol Metab, 1976. 43(1): p. 152-8.

Density	1.5±0.1 g/cm3
Boiling Point	337.2ºC at 760mmHg
Melting Point	>300 °C(lit.)
Molecular Formula	C₄H₄N₂OS
Molecular Weight	128.152
Flash Point	157.7ºC
Exact Mass	128.004440
PSA	80.74000
LogP	-0.28
Vapour Pressure	5.45E-05mmHg at 25°C
Index of Refraction	1.678
Storage condition	2-8°C
Water Solubility	0.5 g/L

2-Thiouracil MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR1575000

CHEMICAL NAME :: Uracil, 2-thio-

CAS REGISTRY NUMBER :: 141-90-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C4-H4-N2-O-S

MOLECULAR WEIGHT :: 128.16

WISWESSER LINE NOTATION :: T6MYMVJ BUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/4W-C

TOXIC EFFECTS :: Endocrine - changes in thyroid weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/14W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid weight (goiter) Tumorigenic - increased incidence of tumors in susceptible strains

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 184 gm/kg/73W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 484 mg/kg

SEX/DURATION :: female 1-26 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - endocrine system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 924 mg/kg

SEX/DURATION :: female 26-41 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1600 mg/kg

SEX/DURATION :: female 1-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 22750 mg/kg

SEX/DURATION :: female 91 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :: Phage inhibition capacity

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 100 mmol/L

REFERENCE :: MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949- Volume(issue)/page/year: 31,11,1979 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,85,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,85,1974 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0277 No. of Facilities: 6 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1776 (estimated) No. of Female Employees: 634 (estimated)

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P281
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful
Risk Phrases	R40
Safety Phrases	S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YR1575000
HS Code	29335995

Precursor 9
CAS#:1257309-84-4 1-[N-(1,3-dipiv... CAS#:333-49-3 4-Aminopyrimidi... CAS#:10601-80-6 Ethyl 3,3-dieth... CAS#:75039-91-7 ethyl 3-(N-meth...
CAS#:87769-48-0 2,2-dimethyl-1,... CAS#:6965-19-1 4 (1H)-Pyrimidi... CAS#:874-14-6 1,3-Dimethyluracil CAS#:666713-60-6 (Z)-ethyl 3-hyd...
CAS#:7424-91-1 Methyl 3,3-dime...
DownStream 9
CAS#:3934-20-1 2,4-Dichloropyr... CAS#:33643-94-6 4(3H)-Pyrimidin... CAS#:21052-18-6 2’,3’,5’-Tri-O-... CAS#:65-71-4 Thymine
CAS#:874-14-6 1,3-Dimethyluracil CAS#:6327-98-6 3-methyl-2-meth... CAS#:6330-98-9 1H-4-Pyrimidino... CAS#:66-22-8 Uracil
CAS#:51953-18-5 4-Pyrimidinol

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-Thioxo-1,2,3,4-tetrahydropyrimidin-4-one

tiouracyl

2-Thiouracil

2,3-dihydro-2-thioxo-(1H)pyrimidin-4-one

4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo-

2-Mercapto-4-pyrimidone

2-Sulfanylpyrimidin-4(3H)-one

uracil, 2-thio-

THIURACIL

2-Thioxo-2,3-dihydro-4(1H)-pyrimidinone

2-TU

Nobilen

Thiouracil

2-Mercapto-4-hydroxypyrimidine

4(3H)-pyrimidinone, 2-mercapto-

2-Thioxo-2,3-dihydropyrimidin-4(1H)-one

4-Hydroxy-2-mercaptopyrimidine

4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine

EINECS 205-508-8

Thiouraci

MFCD00006039

DERACIL

2-sulfanylpyrimidin-4-ol

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China
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China
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China
Product Name: TIANFU CHEM--2-Thiouracil
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Purity: 99.0%
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2-Thiouracil

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