Tetrahedron

Mild, powerful, and robust methods for esterification, amide formation, and thioesterification between acid chlorides and alcohols, amines, thiols, respectively

H Nakatsuji, M Morimoto, T Misaki, Y Tanabe

Index: Nakatsuji, Hidefumi; Morimoto, Mami; Misaki, Tomonori; Tanabe, Yoo Tetrahedron, 2007 , vol. 63, # 48 p. 12071 - 12080

Full Text: HTML

Citation Number: 22

Abstract

We developed two efficient practical methods for esterification, amide formation, and thioesterification between acid chlorides and alcohols, amines, thiols, respectively. The present mild and robust reaction was performed by two separate methods both by combining cheap and readily available amines, N-methylimidazole, and N, N, N′, N′- tetramethylethylenediamine (TMEDA). Method A uses catalytic N-methylimidazole and ...