e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Biomimetic Carbene??Catalyzed Oxidations of Aldehydes Using TEMPO

…, S De Sarkar, S Grimme, A Studer

Index: Guin, Joyram; De Sarkar, Suman; Grimme, Stefan; Studer, Armido Angewandte Chemie - International Edition, 2008 , vol. 47, # 45 p. 8727 - 8730

Full Text: HTML

Citation Number: 143

Abstract

Pyruvate ferredoxin oxidoreductase (PFOR), which catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA and CO2, belongs to the family of 2-keto acid oxidoreductases.[1] This CoA-dependent enzyme uses thiamine pyrophosphate (TPP) as an additional cofactor. The anaerobic decarboxylation is a reversible process, and the two electrons obtained during one turnover are transferred to ferredoxine via [Fe4S4] clusters.[ ...

2-Pyridinecarboxaldehyde Structure

2-Pyridinecarbo...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

pyridine-2-carboxylic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

pyridine-2-carb...

2-Thiophenecarboxaldehyde Structure

2-Thiophenecarb...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

thiophene-2-carboxylic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

thiophene-2-car...

Cinnamic aldehyde Structure

Cinnamic aldehyde

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

(E)-cinnamic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

(E)-cinnamic ac...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

4-((E)-2-methoxy-vinyl)-benzaldehyde Structure

4-((E)-2-methox...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

4-((E)-2-methoxy-vinyl)-benzoic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

4-((E)-2-methox...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

2-(Trifluoromethyl)benzaldehyde Structure

2-(Trifluoromet...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

2-trifluoromethyl-benzoic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

2-trifluorometh...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

4-Vinylbenzaldehyde Structure

4-Vinylbenzaldehyde

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

4-vinyl-benzoic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

4-vinyl-benzoic...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

4-Nitrobenzaldehyde Structure

4-Nitrobenzaldehyde

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

4-nitro benzoic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

4-nitro benzoic...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

4-(DIETHOXYMETHYL)BENZALDEHYDE Structure

4-(DIETHOXYMETH...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

4-diethoxymethyl-benzoic acid 2,2,6,6-tetramethylpiperidin-1-yl ester Structure

4-diethoxymethy...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

4-(1,3-dithiolan-2-yl)benzaldehyde Structure

4-(1,3-dithiola...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

4-[1,3]dithiolan-2-yl-benzoic acid 2,2,6,6-tetramethylpiperidin-1-yl ester Structure

4-[1,3]dithiola...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

Benzaldehyde Structure

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

(2,2,6,6-tetramethylpiperidin-1-yl) benzoate Structure

(2,2,6,6-tetram...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

3-Chlorobenzaldehyde Structure

3-Chlorobenzaldehyde

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

3-chloro-benzoic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

3-chloro-benzoi...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

4-Bromobenzaldehyde Structure

4-Bromobenzaldehyde

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

N/A Structure

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

2-Fluorobenzaldehyde Structure

2-Fluorobenzaldehyde

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

2-fluoro-benzoic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

2-fluoro-benzoi...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

2-Naphthaldehyde Structure

2-Naphthaldehyde

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

naphthalene-2-carboxylic acid 2,2,6,6-tetramethylpiperidin-1-yl ester Structure

naphthalene-2-c...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

Methyl 4-formylbenzoate Structure

Methyl 4-formyl...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

terephthalic acid 1-methyl ester 4-(2,2,6,6-tetramethylpiperidin-1-yl) ester Structure

terephthalic ac...

Crotonaldehyde Structure

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

~0%

N/A Structure

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

3-Phenylpropanal Structure

3-Phenylpropanal

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

3-phenyl-propionic acid 2,2,6,6-tetramethyl-piperidin-1-yl ester Structure

3-phenyl-propio...

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

Phenylglyoxal Structure

~0%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

oxo-phenyl-acetic acid 2,2,6,6-tetramethyl-piperidin-1-yl Structure

oxo-phenyl-acet...

Cinnamic aldehyde Structure

Cinnamic aldehyde

Methanol Structure

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

~%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

Detail

2,2,6,6-Tetramethylpiperidinooxy Structure

2,2,6,6-Tetrame...

Benzaldehyde Structure

~93%

2,2,6,6-Tetramethylpiperidin-1-ol Structure

2,2,6,6-Tetrame...

(2,2,6,6-tetramethylpiperidin-1-yl) benzoate Structure

(2,2,6,6-tetram...

Thermolysis of N??tetramethylpiperidinyl triphenylacetate: h...

[Henry-Riyad, Huda; Tidwell, Thomas T. Journal of Physical Organic Chemistry, 2003 , vol. 16, # 8 p. 559 - 563]

Surface-Mediated Reactions. 9. Selective Oxidation of Primar...

[Fields, John D.; Kropp, Paul J. Journal of Organic Chemistry, 2000 , vol. 65, # 19 p. 5937 - 5941]