1, 3-Dipolar Cycloaddition Reactivities of Perfluorinated Aryl Azides with Enamines and Strained Dipolarophiles

S Xie, SA Lopez, O Ramstrom, M Yan…

Index: Jung, Michael E.; Chamberlain, Brian T.; Ho, Chi-Lee C.; Gillespie, Eugene J.; Bradley, Kenneth A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 363 - 367

Full Text: HTML

Citation Number: 24

Abstract

... J. Am. ... cycloadditions of 5–8 and aryl azides (a-h) are summarized in Table 2. The reactivities of PFAAs with phenylacetaldehyde-derived enamines follow the same trend as that of acetophenone-derived enamines but have k c that are 5–10-fold greater, likely due to of the ...