2,4,6-Trimethylaniline

Modify Date: 2026-07-13 10:34:23

2,4,6-Trimethylaniline Structure
2,4,6-Trimethylaniline structure
 Common Name 2,4,6-Trimethylaniline
CAS Number 88-05-1 Molecular Weight 135.206
Density 1.0±0.1 g/cm3 Boiling Point 231.3±9.0 °C at 760 mmHg
Molecular Formula C9H13N Melting Point -5 °C
MSDS Chinese USA Flash Point 96.1±0.0 °C
Symbol GHS06
GHS06		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2,4,6-Trimethylaniline
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.0±0.1 g/cm3
Boiling Point 231.3±9.0 °C at 760 mmHg
Melting Point -5 °C
Molecular Formula C9H13N
Molecular Weight 135.206
Flash Point 96.1±0.0 °C
Exact Mass 135.104797
PSA 26.02000
LogP 2.32
Vapour Pressure 0.1±0.5 mmHg at 25°C
Index of Refraction 1.553
InChIKey KWVPRPSXBZNOHS-UHFFFAOYSA-N
SMILES Cc1cc(C)c(N)c(C)c1
Water Solubility IMMISCIBLE

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BZ0700000
CHEMICAL NAME :
Aniline, 2,4,6-trimethyl-
CAS REGISTRY NUMBER :
88-05-1
LAST UPDATED :
199806
DATA ITEMS CITED :
29
MOLECULAR FORMULA :
C9-H13-N
MOLECULAR WEIGHT :
135.23
WISWESSER LINE NOTATION :
ZR B1 D1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
743 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
506 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
290 mg/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
372 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
220 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
338 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
338 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
372 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1522 mg/kg/9W-I
TOXIC EFFECTS :
Blood - change in clotting factors Blood - changes in erythrocyte (RBC) count Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 ug/m3/24H/14W-C
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1083 mg/kg/45D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - retinal changes (pigmentary depositions, retinitis, other)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4000 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Endocrine - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
DNA damage

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
3 mmol/L/4H
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,317,1980 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,177,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,177,1982 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H302 + H312-H315-H319-H330
Precautionary Statements P260-P280-P284-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;
Risk Phrases R23/24/25;R33
Safety Phrases S26-S28-S36/37-S45-S28A
RIDADR UN 2810 6.1/PG 2
WGK Germany 3
RTECS BZ0700000
Packaging Group III
Hazard Class 6.1
HS Code 2921499090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2921430090
Summary HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles11

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Stability of erythrocyte membrane and overall hemostasis potential - A biocompatibility study of mebrofenin and other iminodiacetic acid derivatives.

Pharmacol. Rep. 67 , 1230-9, (2015)

Intravenous injection seems to be the most convenient way of administering drugs and contrast agents, which makes components of the blood the first and usually unwanted target of their action. Binding...

Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ("comet") assay.

Teratog. Carcinog. Mutagen. 19(5) , 323-7, (1999)

The alkaline single cell gel electrophoresis (SCGE) or "comet" assay under alkaline conditions was used to measure DNA damage in the liver cells of B6C3F1 male mice exposed to 2,4-dimethylaniline and ...

Assessment of aniline derivatives-induced DNA damage in the liver cells of B6C3F1 mice using the alkaline single cell gel electrophoresis ('comet') assay.

Cancer Lett. 147(1-2) , 1-4, (1999)

The alkaline single cell gel electrophoresis (SCGE) or 'comet' assay under alkaline conditions was used to measure DNA damage in the liver cells of B6C3F1 male mice exposed to 2,4-dimethylaniline and ...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 201-794-3
Benzenamine,2,4,6-trimethyl
Mesidin
2,4,6-tri-MePhNH2
Aminomesitylene
2,4,6-(Me)3-C6H4NH2
Mesidine
2,4,6-trimethylbenzenamine
2,4,6-trimethyl-aniline
2-Amino-1,3,5-trimethylbenzene
2,4,6-Trimethyl aniline
Mesitylamine
2,4,6-Trimethylaniline
2-Aminomesitylene
Aniline,2,4,6-trimethyl
MFCD00007740

 2,4,6-Trimethylaniline | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of 2,4,6-Trimethylaniline?
A: InChIKey of 2,4,6-Trimethylaniline is KWVPRPSXBZNOHS-UHFFFAOYSA-N.
Q: What is the CAS number of 2,4,6-Trimethylaniline?
A: CAS number of 2,4,6-Trimethylaniline is 88-05-1.
Q: What is the polar surface area (PSA) of 2,4,6-Trimethylaniline?
A: Polar surface area (PSA) of 2,4,6-Trimethylaniline is 26.02000.
Q: What is the safety information for 2,4,6-Trimethylaniline?
A: Safety information for 2,4,6-Trimethylaniline: S26-S28-S36/37-S45-S28A.
Q: What is the molecular formula of 2,4,6-Trimethylaniline?
A: Molecular formula of 2,4,6-Trimethylaniline is C9H13N.
Q: What is the melting point of 2,4,6-Trimethylaniline?
A: Melting point of 2,4,6-Trimethylaniline is -5 °C.
Q: What is the boiling point of 2,4,6-Trimethylaniline?
A: Boiling point of 2,4,6-Trimethylaniline is 231.3±9.0 °C at 760 mmHg.
Q: What are the upstream materials of 2,4,6-Trimethylaniline?
A: Related upstream materials(CAS) of 2,4,6-Trimethylaniline: 576-83-0;5980-97-2;356031-47-5;603-71-4;4028-63-1;108-67-8;938-18-1;1667-04-5.
Q: What is the English name of 2,4,6-Trimethylaniline?
A: The English name of 2,4,6-Trimethylaniline is 2,4,6-Trimethylaniline.
Q: What is the LogP of 2,4,6-Trimethylaniline?
A: LogP of 2,4,6-Trimethylaniline is 2.32.

 2,4,6-Trimethylanilinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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