Studies on pyrazolo [3, 4-d] pyrimidine derivatives. XV. Reactions involving the formation of the anion of the Reissert compound derived from 1H-pyrazolo [3, 4-d] …

T HIGASHINO, S SATO, A MIYASHITA…

Index: Hagishino, Takeo; Sato, Susumu; Miyashita, Akira; Katori, Tatsuhiko Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4078 - 4086

Full Text: HTML

Citation Number: 1

Abstract

The anion (A) of the Reissert compound (1, 5-benzoyl-4, 5-dihydro-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidine-4-carbonitrile) was found to react with electrophiles in two ways. One is nucleophilic attack of the anion A. The other is self-decomposition of the anion A. Thus, A underwent nucleophilic attack with aromatic and aliphatic aldehydes (4a-j), resulting in the formation of the corresponding α-aryl (or alkyl)-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4- ...