Organic Chemistry Frontiers 2018-03-30

Palladium-catalyzed direct approach to α-CF3 aryl ketones from arylboronic acids

Bo Jiang, Xiaofei Zhang, Chunhao Yang

Index: 10.1039/C8QO00289D

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Abstract

A concise and practical method for the synthesis of α-CF3 aryl ketones using stable and commercially available arylboronic acids and ICH2CF3 was reported. The α-CF3 aryl ketones could be easily obtained using a CO balloon (1 atm) in the presence of a palladium catalyst. This protocol provided a direct approach for the synthesis of α-CF3 aryl ketones from carbonylative cross-coupling reactions from easily accessible starting materials and the one-step reaction was conducted under a very practical CO pressure.