A Versatile Protocol for Copper??Catalyzed Cyanation of Aryl and Heteroaryl Bromides with Acetone Cyanohydrin

T Schareina, A Zapf, A Cotte, M Gotta…

Index: Schareina, Thomas; Zapf, Alexander; Cotte, Alain; Gotta, Matthias; Beller, Matthias Advanced Synthesis and Catalysis, 2011 , vol. 353, # 5 p. 777 - 780

Full Text: HTML

Citation Number: 49

Abstract

In general, it is well known for metal-catalyzed cyanations that an increased concentration of CN − blocks the active metal center.11 This problem can be circumvented by decreasing the solubility of cyanide in the respective solvent, or by using salts or complexes that deliver CN − slowly, for example, K 4 [Fe(CN) 6 ]. However, for larger scale (>kg-scale) applications it is desirable to control the concentration of CN − even more precisely. Therefore, dosage of ...