Synthesis and calcium antagonistic activity of diethyl styrylbenzylphosphonates

…, G Baziard-Mouysset, JL Stigliani, M Payard…

Index: Younes, S.; Tchani, G.; Baziard-Mouysset, G.; Stigliani, J. L.; Payard, M.; et al. European Journal of Medicinal Chemistry, 1994 , vol. 29, # 1 p. 87 - 94

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Citation Number: 7

Abstract

Abstract Twenty-three new phosphonic ester derivatives of stilbene exhibiting structural analogies with fostedil are described. Examination of calcium antagonism showed that this activity could not be increased by introducing electron-withdrawing, electron-releasing or lipophilic substituents. Only compounds containing fluorine at the 2 or 4 positions exhibited similar activity to the model.