. beta.-Lapachone: synthesis of derivatives and activities in tumor models

K Schaffner-Sabba, KH Schmidt-Ruppin…

Index: Schaffner-Sabba, Karl; Schmidt-Ruppin, Karl H.; Wehrli, Walter; Schuerch, ALfred R.; Wasley, Jan W. F. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 990 - 994

Full Text: HTML

Citation Number: 128

Abstract

synthesized in this series by using the naphthalenediones 3 as intermediates. Of these, the dimethoxy derivative 3d has previously been synthesized* starting from ethyl homoveratrate? For the preparation of the naphthoquinones 38-c, the methylindenes la-c were synthesized from the corresponding 1-indanones and oxidized with dichromate to the phenylacetic acids 2. loJ1 Cyclization of the corresponding ethyl esters of 2 as shown in ...