An improved synthesis of functionalized biphenyl-based phosphine ligands

H Tomori, JM Fox, SL Buchwald

Index: Tomori, Hiroshi; Fox, Joseph M.; Buchwald, Stephen L. Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5334 - 5341

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Citation Number: 221

Abstract

Functionalized dicyclohexyl-and di-tert-butylphosphinobiphenyl ligands are prepared by the reaction of arylmagnesium halides with benzyne, followed by the addition of a chlorodialkylphosphine. This one-pot procedure is considerably less expensive and time- consuming than the method used previously to prepare such ligands. The cost of introducing the dicyclohexylphosphine group can be decreased by preparing ...