The hydrogenolysis of N-benzyl groups with magnesium and ammonium formate

SN Babu, GR Srinivasa, DC Santhosh…

Index: Babu, S.N. Narendra; Srinivasa; Santhosh; Gowda, D. Channe Journal of Chemical Research, 2004 , # 1 p. 66 - 67

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Citation Number: 3

Abstract

Benzyl (Bn) groups are very popular for protecting amines, alcohols and thiols.1,2 The facile removal of protecting groups from labile or reactive organic functionalities is an important objective. Although a number of methods have been reported for debenzylation, catalytic transfer hydrogenolysis,3,4 which involves a catalyst and hydrogen donor is one of the most commonly used methods. The application of Pd/C with ammonium formate for the rapid ...