Australian journal of chemistry

Synthesis and Preliminary Pharmacological Evaluation of 4＇-Arylmethyl Analogues of Clozapine. I. The Effect of Aromatic Substituents

B Capuano, IT Crosby, EJ Lloyd, DA Taylor

Index: Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A. Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576

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Citation Number: 32

Abstract

Abstract As part of a research program to develop compounds with mixed dopamine D 4 and serotonin 5-HT 2A antagonist activity with potential for the treatment of schizophrenia, we report a family of compounds based on structural modification of the atypical antipsychotic, clozapine (2). The chemical synthesis, structural characterization and pharmacological evaluation of a series 4-arylmethyl analogues of clozapine are described. Preliminary ...