Tetrahedron

Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

…, SK Smirnov, TA Stroganova, W Bender, GD Krapivin

Index: Butin, Alexander V.; Smirnov, Sergey K.; Stroganova, Tatyana A.; Bender, Wolfgang; Krapivin, Gennady D. Tetrahedron, 2007 , vol. 63, # 2 p. 474 - 491

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Citation Number: 59

Abstract

A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl) furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3- position of indole nucleus.