Convenient Synthesis of Structurally Novel 1, 3??Disubstituted Azetidine Derivatives

RK Kharul, A Goswami, A Gite, AK Godha…

Index: Kharul, Rajendra K.; Goswami, Amitgiri; Gite, Archana; Godha, Atul K.; Jain, Mukul; Patel, Pankaj R. Synthetic Communications, 2008 , vol. 38, # 11 p. 1703 - 1717

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Citation Number: 4

Abstract

Abstract A convenient synthesis of structurally novel 1, 3??disubstituted azetidine derivatives is described. The approach involves condensation of an azetidine building block with sulfonylated carbamic acid methyl ester, subsequently followed by quenching the imidoyl chloride with amines. Different derivatives were prepared by substituting benzhydrol as well as benzenesulfonamide as part of the core structure.