Synthesis and biological activities of isogranulatimide analogues

…, S Léonce, J Hickman, B Pfeiffer, M Prudhomme

Index: Hugon, Bernadette; Anizon, Fabrice; Bailly, Christian; Golsteyn, Roy M.; Pierre, Alain; Leonce, Stephane; Hickman, John; Pfeiffer, Bruno; Prudhomme, Michelle Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 17 p. 5965 - 5980

Full Text: HTML

Citation Number: 42

Abstract

The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in vitro cytotoxicities toward four tumor cell lines (one murine L1210 leukemia, and three human cell lines: DU145 prostate carcinoma, A549 non- small cell lung carcinoma, and HT29 colon carcinoma) are described. The affinity for DNA of some representative compounds and their ability to induce DNA cleavage mediated by ...