Rh (I)-catalyzed arylation of heterocycles via CH bond activation: expanded scope through mechanistic insight

…, AM Berman, RG Bergman, JA Ellman

Index: Lewis, Jared C.; Berman, Ashley M.; Bergman, Robert G.; Ellman, Jonathan A. Journal of the American Chemical Society, 2008 , vol. 130, # 8 p. 2493 - 2500

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Citation Number: 191

Abstract

A practical, functional group tolerant method for the Rh-catalyzed direct arylation of a variety of pharmaceutically important azoles with aryl bromides is described. Many of the successful azole and aryl bromide coupling partners are not compatible with methods for the direct arylation of heterocycles using Pd (0) or Cu (I) catalysts. The readily prepared, low molecular weight ligand, Z-1-tert-butyl-2, 3, 6, 7-tetrahydrophosphepine, which coordinates to Rh in ...