An Efficient Preparation of N-Methyl-α-amino Acids from N-Nosyl-α-amino Acid Phenacyl Esters

…, EL Belsito, R De Marco, A Liguori, F Perri…

Index: Leggio, Antonella; Belsito, Emilia Lucia; De Marco, Rosaria; Liguori, Angelo; Perri, Francesca; Viscomi, Maria Caterina Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1386 - 1392

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Citation Number: 6

Abstract

In this paper we describe a simple and efficient solution-phase synthesis of N-methyl-N- nosyl-α-amino acids and N-Fmoc-N-methyl-α-amino acids. This represents a very important application in peptide synthesis to obtain N-methylated peptides in both solution and solid phase. The developed methodology involves the use of N-nosyl-α-amino acids with the carboxyl function protected as a phenacyl ester and the methylating reagent ...