Tetrahedron

Fluoroform: an efficient precursor for the trifluoromethylation of aldehydes

B Folléas, I Marek, JF Normant, L Saint-Jalmes

Index: Folleas, Benoit; Marek, Ilan; Normant, Jean-F.; Saint-Jalmes, Laurent Tetrahedron, 2000 , vol. 56, # 2 p. 275 - 283

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Citation Number: 86

Abstract

Classical methods for the synthesis of trifluoromethylated aromatics come from the beginning of this century. Indeed, Swarts discovered that antimony trifluoride could be used to convert benzotrichloride into benzotrifluoride. 6 Later, it was found that hydrogen fluoride could also fluorinate benzotrichloride to yield the trifluoride. 7 These methods are still used today, but have a number of disadvantages relating to the harsh conditions they impose and their toxicity. These facts have led to the ...