Tetrahedron

Cytotoxic and NF-κB inhibitory sesquiterpene lactones from Piptocoma rufescens

…, F Jiménez, R García, M Mejía, H Chai, JC Gallucci…

Index: Ren, Yulin; Acuna, Ulyana Munoz; Jimenez, Francisco; Garcia, Ricardo; Mejia, Melciades; Chai, Heebyung; Gallucci, Judith C.; Farnsworth, Norman R.; Soejarto, Djaja D.; Carcache De Blanco, Esperanza J.; Kinghorn, A. Douglas Tetrahedron, 2012 , vol. 68, # 12 p. 2671 - 2678

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Citation Number: 21

Abstract

Six new (1–6) and eight known germacranolide-type sesquiterpene lactones, along with several known phenylpropanol coumarates and methylated flavonoids, were isolated from the leaves of Piptocoma rufescens, collected in the Dominican Republic. The new compounds were identified by analysis of their spectroscopic data, with the molecular structure of 3 being established by single-crystal X-ray diffraction. The absolute ...