A facile and new approach to synthesize 2-amino-4-(4-amoinophenyl)-1H-1, 3-diazol-1-yl-alkylaminomethanethiones

RK Verma, M Aggarwal, M Bansal, IP Kaur

Index: Verma, Raman K.; Aggarwal, Monika; Bansal, Manisha; Kaur, Inder Preet Medicinal Chemistry Research, 2007 , vol. 15, # 9 p. 483 - 491

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Abstract

Abstract An “intellectual connection” approach to design a facile and new synthesis of suitably substituted 2-aminoimidazole-based precursors of expected antiasthmatic agents through a benzidine type of rearrangement of 2-phenylazoimidazole and subsequent coupling of the product thus obtained with alkylisothiocyanates involving a degenerative operation, thereby improving the time frame of the overall synthetic sequence, is reported. ...