Design of new β 1-selective adrenoceptor ligands as potential radioligands for in vivo imaging

…, T Wichter, W Schmitz, O Schober, M Schäfers

Index: Kopka, Klaus; Wagner, Stefan; Riemann, Burkhard; Law, Marilyn P; Puke, Carsten; Luthra, Sajinder K; Pike, Victor W; Wichter, Thomas; Schmitz, Wilhelm; Schober, Otmar; Schaefers, Michael Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3513 - 3527

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Citation Number: 27

Abstract

In general, the failing human heart is characterized by a selective reduction in β1- adrenoceptors (β1-ARs) without change in β2-AR density. Medical imaging techniques, either single photon emission computed tomography (SPECT) or positron emission tomography (PET) with appropriate radioligands, offer the possibility of assessing β- adrenoceptor density non-invasively in humans. To date, neither a SPECT nor a PET ...