The Journal of Organic Chemistry

Synthesis of halogenated pyridines via the copper (I) chloride-catalyzed addition of polyhaloacetonitriles to olefins

RG Pews, Z Lysenko

Index: Pews, R. Garth; Lysenko, Zenon Journal of Organic Chemistry, 1985 , vol. 50, # 25 p. 5115 - 5119

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Citation Number: 33

Abstract

Halogenated acetonitriles add smoothly to acrolein, methacrolein, and methacrolein dimethyl acetal in the presence of a catalytic amount of CuCl and triphenylphosphine, tri-n- butylphosphine, or triethylamine to give halogenated difunctional adducts. The adducts have been cyclized in high yields under acidic conditions to halogenated pyridines.