Synthesis and biological evaluation of novel 2, 4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy

J Thurmond, MER Butchbach, M Palomo…

Index: Journal of Medicinal Chemistry, , vol. 51, # 3 p. 449 - 469

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Citation Number: 76

Abstract

... Journal of Medicinal ... Sturlugata 8, IS-101, Reykjavik, Iceland, Department of Molecular and Cellular Biochemistry, College of Medicine and Public ... Our initial medicinal chemistry effort explored a series of C5 substituted benzyl ether based 2,4-diaminoquinazoline derivatives that ...