The Journal of Organic Chemistry

1, 2-Benzisoxazol-3-yl diphenyl phosphate: a new, reactive activating agent for the synthesis of amides, esters, and peptides via condensation

M Ueda, H Oikawa

Index: Ueda, Mitsuru; Oikawa, Hideaki Journal of Organic Chemistry, 1985 , vol. 50, # 6 p. 760 - 763

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Citation Number: 43

Abstract

A new activating agent for condensations, 1, 2-benzisoxazol-3-y1 diphenyl phosphate (11, was readily prepared in high yield by the reaction of 1, 2-benzisoxazol-3-01 (2) with diphenyl phosphoiochloridate (3) in the presence of triethylamine in benzene. The reaction of the carboxylic acids with the amines in the presence of 1 was investigated by two procedures, a two-step method and a one-step procedure. Both methods gave the ...