Amination of Benzoxazoles and 1, 3, 4??Oxadiazoles Using 2, 2, 6, 6??Tetramethylpiperidine??N??oxoammonium Tetrafluoroborate as an Organic Oxidant

S Wertz, S Kodama, A Studer

Index: Wertz, Sebastian; Kodama, Shintaro; Studer, Armido Angewandte Chemie - International Edition, 2011 , vol. 50, # 48 p. 11511 - 11515

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Citation Number: 69

Abstract

Functionalized azoles occur as substructures in a variety of natural products [1] and show great potential as valuable lead compounds for the development of novel therapeutics.[2] Among them, 2-aminobenzoxazoles display high activity as partial antagonists for 5-HT receptors (5-HT= 5-hydroxytryptamine, seretonine) which are promising targets for the treatment of Alzheimer s disease and schizophrenia.[3] Moreover, numerous other drug ...