Design, synthesis, molecular modeling, and biological evaluation of sulfanilamide-imines derivatives as potential anticancer agents

…, AA Allafi, IA Mrema, M Erhuma, A Hermann…

Index: Mohamed, Sofian S.; Tamer, Abdalkarem R.; Bensaber, Salah M.; Jaeda, Mousa I.; Ermeli, Nouri B.; Allafi, Aemen Ali; Mrema, Ibrahim A.; Erhuma, Mabrouk; Hermann, Anton; Gbaj, Abdul M. Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 , vol. 386, # 9 p. 813 - 822

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Citation Number: 8

Abstract

Abstract A series of sulfanilamide Schiff base derivatives (1 to 15) have been designed as potential antitubulin agents depending on the chemical structures of combretastatine A-4 and isoquinoline sulfamate (antimitotic agents under investigation). The designed compounds were synthesized by microwave chemical synthesis, their purity was confirmed by melting point and HPLC and chemical structures were determined by FT-IR, UV, and 1 ...