e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

European journal of medicinal chemistry

Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2

K Juvale, K Stefan, M Wiese

Index: Juvale, Kapil; Stefan, Katja; Wiese, Michael European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 115 - 126

Full Text: HTML

Citation Number: 41

Abstract

Abstract Multidrug resistance (MDR) often leads to a failure of cancer chemotherapy. Breast Cancer Resistance Protein (BCRP/ABCG2), a member of the superfamily of ATP binding cassette proteins has been found to confer MDR in cancer cells by transporting molecules with amphiphilic character out of the cells using energy from ATP hydrolysis. Inhibiting BCRP can be a solution to overcome MDR. We synthesized a series of flavones, 7, 8- ...

N/A Structure

~65%

DiMNF Structure

1-(2-hydroxynaphthalen-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one Structure

1-(2-hydroxynap...

~63%

4'-methoxy-5,6-benzoflavone Structure

4'-methoxy-5,6-...

4-Methoxybenzaldehyde Structure

4-Methoxybenzal...

~%

4'-methoxy-5,6-benzoflavone Structure

4'-methoxy-5,6-...

3-phenyl-1-(2'-hydroxynaphthyl)-2-propen-1-one Structure

3-phenyl-1-(2'-...

~59%

β-Naphthoflavone Structure

β-Naphthoflavone

veratraldehyde Structure

~%

4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-3-hydroxy-7-methoxy- Structure

4H-1-Benzopyran...

Paeonol Structure

~%

4H-1-Benzopyran-4-one,2-(3,4-dimethoxyphenyl)-3-hydroxy-7-methoxy- Structure

4H-1-Benzopyran...

Paeonol Structure

4-Methoxybenzaldehyde Structure

4-Methoxybenzal...

~%

4H-1-Benzopyran-4-one,3-hydroxy-7-methoxy-2-(4-methoxyphenyl)- Structure

4H-1-Benzopyran...

Morin Structure

methyl iodide Structure

~73%

Pentamethoxymorin Structure

Pentamethoxymorin

2-hydroxy-4'-methoxychalcone Structure

2-hydroxy-4'-me...

~%

3-methoxy-2-(4-methoxyphenyl)chromen-4-one Structure

3-methoxy-2-(4-...

4-Methoxybenzaldehyde Structure

4-Methoxybenzal...

~%

3-methoxy-2-(4-methoxyphenyl)chromen-4-one Structure

3-methoxy-2-(4-...

Ortho-Hydroxyacetophenone Structure

Ortho-Hydroxyac...

~%

3-methoxy-2-(4-methoxyphenyl)chromen-4-one Structure

3-methoxy-2-(4-...

3-Hydroxyflavone Structure

3-Hydroxyflavone

methyl iodide Structure

~76%

3-Methoxy-2-phenyl-4H-chromen-4-one Structure

3-Methoxy-2-phe...

2-Propen-1-one,1-(2-hydroxyphenyl)-3-phenyl-, (2E)- Structure

2-Propen-1-one,...

~%

3-Methoxy-2-phenyl-4H-chromen-4-one Structure

3-Methoxy-2-phe...

Benzaldehyde Structure

~%

3-Methoxy-2-phenyl-4H-chromen-4-one Structure

3-Methoxy-2-phe...

Ortho-Hydroxyacetophenone Structure

Ortho-Hydroxyac...

~%

3-Methoxy-2-phenyl-4H-chromen-4-one Structure

3-Methoxy-2-phe...

Synthesis and biological evaluation of flavones and benzofla...

[European Journal of Medicinal Chemistry, , vol. 67, p. 115 - 126]

Synthesis and biological evaluation of flavones and benzofla...

[European Journal of Medicinal Chemistry, , vol. 67, p. 115 - 126]