Tetrahedron

Réductions microbiologiques stéréosélectivés des Δ-4 céto-3 stéroïdes

A Fauve, A Kergomard

Index: Fauve, A.; Kergomard, A. Tetrahedron, 1981 , vol. 37, p. 899 - 901

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Citation Number: 9

Abstract

In anaerobic conditions the reduction of Δ-4 3-keto steroids by Clostridium paraputrificum leads either to the 3-keto 5β compounds or to the corresponding 3α-hydroxytetrahydro-5β derivatives. This stereospecific bioconversion of αβ-unsaturated 3-keto steroids is shown to be directed by the substrate concentration. The conversion of Δ-4 cholestenone to coprostanone or coprostanol is not observed.