Etiocholanolone
Etiocholanolone structure
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Common Name | Etiocholanolone | ||
|---|---|---|---|---|
| CAS Number | 53-42-9 | Molecular Weight | 290.440 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 413.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H30O2 | Melting Point | 148～150°C (lit.) | |
| MSDS | Chinese USA | Flash Point | 176.4±21.3 °C | |
Use of EtiocholanoloneEtiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2]. |
| Name | 3α-hydroxy-5β-androstan-17-one |
|---|---|
| Synonym | More Synonyms |
| Description | Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect)[2]. |
| In Vivo | Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 413.1±45.0 °C at 760 mmHg |
| Melting Point | 148～150°C (lit.) |
| Molecular Formula | C19H30O2 |
| Molecular Weight | 290.440 |
| Flash Point | 176.4±21.3 °C |
| Exact Mass | 290.224579 |
| PSA | 37.30000 |
| LogP | 3.75 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.536 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F,Xn |
| Risk Phrases | 11-20/21/22-36 |
| Safety Phrases | 16-36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| Precursor 9 | |
|---|---|
| DownStream 1 | |
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| 3a-Hydroxy-5b-androstane-17-one |
| Androsterone, (5β)- |
| 3alpha-hydroxy-5beta-androstan-17-one |
| 5β-Androsterone |
| (5b)-Androsterone |
| 5-Isoandrosterone |
| 3α-hydroxy-5β-androstane-17-one |
| 5β-Androstan-17-one, 3α-hydroxy- |
| 5BETA-ANDROSTERONE |
| MFCD00064133 |
| (3α,5β)-3-Hydroxyandrostan-17-one |
| ETIOCHOLANOLON |
| 3α-Etiocholanolone |
| Androstan-17-one, 3-hydroxy-, (3α,5β)- |
| 19-noretiocholanolone |
| ETIOCHOLANONE |
| 3a-Etiocholanolone |
| 3α-hydroxy-5β-androstan-17-one |
| 5b-Androsterone |
| Etiocholan-3a-ol-17-one |
| Etiocholan-3α-ol-17-one |
| Etiocholan-3.α.-ol-17-one |
| EINECS 200-835-2 |
| Etiocholanolone |