Synthesis and oral antiallergic activity of carboxylic acids derived from imidazo [2, 1-c][1, 4] benzoxazines, imidazo [1, 2-a] quinolines, imidazo [1, 2-a] quinoxalines, …

…, PD Kennewell, SS Matharu, P Miller…

Index: Ager; Barnes; Danswan; Hairsine; Kay; Kennewell; Matharu; Miller; Robson; Rowlands; Tully; Westwood Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1098 - 1115

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Citation Number: 91

Abstract

4H-Irnidazo [P, lc][1, 4] benzoxazine-2-carboxylic acid (3) was found to possess potent activity in the IgE-induced rat passive cutaneous anaphylaxis model which may be predictive of clinical antiallergic activity. Compared to disodium cromoglycate (DSCG, l), 3 was less active following iv administration but unlike DSCG showed very significant oral activity. To explore the structural requirements for this activity, a range of tricyclic ...