Tetrahedron Letters

An efficient synthesis of tert-butyl ethers/esters of alcohols/amino acids using methyl tert-butyl ether

N Mallesha, SP Rao, R Suhas, DC Gowda

Index: Mallesha; Prahlada Rao; Suhas; Channe Gowda Tetrahedron Letters, 2012 , vol. 53, # 6 p. 641 - 645

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Citation Number: 8

Abstract

A facile synthesis of a wide variety of tert-butyl ethers and tert-butyl ester derivatives under mild conditions is described. Alcohols etherified with tert-butyl methyl ether as tert-butyl source and solvent, in the presence of sulfuric acid. Many amino acid tert-butyl esters have been synthesized by this procedure. The reaction is simple, inexpensive, easily scaled up, and proceeds without observable racemization. A green method was developed for the ...