L-serine

Modify Date: 2024-01-01 19:32:04

L-serine structure	Common Name	L-serine
	CAS Number	56-45-1	Molecular Weight	105.093
	Density	1.6	Boiling Point	394.8±32.0 °C at 760 mmHg
	Molecular Formula	C₃H₇NO₃	Melting Point	222ºC
	MSDS	Chinese USA	Flash Point	192.6±25.1 °C

Use of L-serine

L-Serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

Name	L-serine
Synonym	More Synonyms

Description	L-Serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
Related Catalog	Research Areas >> Cancer Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. In cell cultures, L-Serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization.L-Serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system[1].
References	[1]. de Koning TJ, et al. L-Serine in disease and development. Biochem J. 2003 May 1;371(Pt 3):653-61.

Density	1.6
Boiling Point	394.8±32.0 °C at 760 mmHg
Melting Point	222ºC
Molecular Formula	C₃H₇NO₃
Molecular Weight	105.093
Flash Point	192.6±25.1 °C
Exact Mass	105.042595
PSA	83.55000
LogP	-1.58
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.519
Storage condition	2~8℃
Water Solubility	250 g/L (20 ºC)

L-serine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT8100000

CHEMICAL NAME :: Serine, L-

CAS REGISTRY NUMBER :: 56-45-1

BEILSTEIN REFERENCE NO. :: 1721404

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C3-H7-N-O3

MOLECULAR WEIGHT :: 105.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81867 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81867 No. of Facilities: 305 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 5855 (estimated) No. of Female Employees: 4144 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	VT8100000
HS Code	29225000

Precursor 8
CAS#:2788-84-3 l-serine methyl... CAS#:71630-31-4 (R)-tert-Butyl ... CAS#:1145-80-8 N-Cbz-L-Serine CAS#:4726-96-9 H-Ser(Bzl)-OH
CAS#:20806-43-3 Z-Ser(Bzl)-OH CAS#:302-84-1 DL-Serine CAS#:56-40-6 Glycine CAS#:1113-60-6 Hydroxypyruvic acid
DownStream 10
CAS#:1113-60-6 Hydroxypyruvic acid CAS#:56-86-0 L-glutamic acid CAS#:107743-37-3 N-Oleoyl-L-Serine CAS#:3262-72-4 Boc-Ser-OH
CAS#:56-88-2 L-Cystathionine CAS#:7732-18-5 Water CAS#:34317-61-8 S-Phenyl-L-cysteine CAS#:348-67-4 D-methionine
CAS#:52809-07-1 Quisqualic acid CAS#:33468-35-8 6-Chloro-L-tryp...

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Long-term application of glycine transporter inhibitors acts antineuropathic and modulates spinal N-methyl-D-aspartate receptor subunit NR-1 expression in rats.

Anesthesiology 121(1) , 160-9, (2014)

Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2....

8DSS-promoted remineralization of initial enamel caries in vitro.

J. Dent. Res. 93(5) , 520-4, (2014)

Peptides containing 8 repeats of aspartate-serine-serine (8DSS) have been shown to promote the nucleation of calcium phosphate from solution into human enamel. Here we tested the ability of 8DSS to pr...

Sulfur amino acid metabolism in Zucker diabetic fatty rats.

Biochem. Pharmacol. 96 , 256-66, (2015)

The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste...

L-Serin

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SERINE,USP

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H-L-SER-OH

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(R)-(-)-Serine

d-ser

Serine, D-

D-Serine

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(S)-(-)-serine

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(-)-Serine

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EINECS 200-274-3

MFCD00064224

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: L-serine
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GL Biochem (Shanghai) Ltd.
China
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BioBioPha
China
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China
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China
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China
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China
Product Name: L-Serine
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: L-Serine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
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L-serine

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