Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

…, O Mesenzani, C Coppo, G Sorba, PL Canonico…

Index: Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A. European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 58 - 66,9

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Citation Number: 14

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2. ... ► Rigid analogues and isosteres of ...