Bioorganic & medicinal chemistry letters

1α, 25-Dihydroxyvitamin D 3-3β-bromoacetate, a potential cancer therapeutic agent: Synthesis and molecular mechanism of action

R Ray, JR Lambert

Index: Ray, Rahul; Lambert, James R. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2537 - 2540

Full Text: HTML

Citation Number: 11

Abstract

Synthesis of 1α, 25-dihydroxyvitamin D3-3β-bromoacetate (1, 25 (OH) 2D3-3-BE), a potential anti-cancer agent is presented. We also report that mechanism of action of 1, 25 (OH) 2D3-3-BE may involve reduction of its catabolism, as evidenced by the reduced and ...