Calcifediol

Modify Date: 2024-01-02 18:32:20

Calcifediol structure	Common Name	Calcifediol
	CAS Number	19356-17-3	Molecular Weight	400.637
	Density	1.0±0.1 g/cm3	Boiling Point	529.2±33.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₄O₂	Melting Point	74-76oC
	MSDS	Chinese USA	Flash Point	221.4±20.0 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Calcifediol

Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).

Name	calcidiol
Synonym	More Synonyms

Description	Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1].
References	[1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.

Density	1.0±0.1 g/cm3
Boiling Point	529.2±33.0 °C at 760 mmHg
Melting Point	74-76oC
Molecular Formula	C₂₇H₄₄O₂
Molecular Weight	400.637
Flash Point	221.4±20.0 °C
Exact Mass	400.334137
PSA	40.46000
LogP	7.53
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.536
Storage condition	−20°C

Calcifediol MSDS(Chinese)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301 + H311-H330-H372
Precautionary Statements	P260-P280-P284-P301 + P310-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	R28
Safety Phrases	28-36/37-45
RIDADR	UN 2811 6
WGK Germany	3
Packaging Group	Ⅱ

Precursor 8
CAS#:61585-29-3 25-Hydroxyprovi... CAS#:104973-29-7 6(S),19-(N,N'-p... CAS#:104875-13-0 (2S,14S)-14-((E... CAS#:87417-16-1 (3-methyl-3-((t...
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DownStream 2
CAS#:140710-90-3 (6R)-6-[(1R,3aS... CAS#:32222-06-3 Calcitriol

Silver dopants for targeted and untargeted direct analysis of unsaturated lipids via infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI).

Rapid Commun. Mass Spectrom. 28(22) , 2461-70, (2014)

Unsaturated lipids play a crucial role in cellular processes as signaling factors, membrane building blocks or energy storage molecules. However, adequate mass spectrometry imaging of this diverse gro...

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

J. Chromatogr. A. 1364 , 214-22, (2014)

We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of...

Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research.

Biomed. Chromatogr. 28(6) , 913-7, (2014)

The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrom...

Didrogyl

1H-indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-a,a,e,7a-tetramethyl-, (eR,1R,3aS,4E,7aR)-

(3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-triene-3,25-diol

25-hydroxyvitamin D3

Ro 8-8892

25-HCC

U 32070E

Vitamin D3 25 Calcifediol

(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol

1H-Indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-α,α,ε,7a-tetramethyl-, (εR,1R,3aS,4E,7aR)-

25-hydroxycholecalciferol

9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-3β,25-DIOL

MFCD00867077

CALCIDIOL

Dedrogyl

9,10-secocholesta-5,7,10-triene-3,25-diol, (3S,5Z,7E)-

25-hydroxyvitamin D

25-hydroxy-cholecalciferol

9,10-Secocholesta-5,7,10(19)-triene-3b,25-diol

9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3β,5Z,7E)-

Calderol

Calcifediol

U-32070E

1H-indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-α,α,ε,7a-tetramethyl-, (1R,3aS,4E,7aR)-

Calcifediol,(εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol

EINECS 242-990-9

Calcidiol,Didrogyl,Hidroferol

Hidroferol

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Calcifediol
Price: ￥758.0/5mg ￥2368.0/25mg ￥2948.0/10mg
Purity: 97.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Calcifediol
Price: $800.0/100mg $1500.0/250mg $2800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 25-Hydroxycholecalciferol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 25-Hydroxyvitamin D3
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Calcidiol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥644/10mg

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Calcifediol

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