Tetrahedron Letters

Efficient Co (OAc) 2-catalyzed aerobic oxidation of EWG-substituted 4-cresols to access 4-hydroxybenzaldehydes

JA Jiang, JL Du, DH Liao, ZG Wang, YF Ji

Index: Jiang, Jian-An; Du, Jia-Lei; Liao, Dao-Hua; Wang, Zhan-Guo; Ji, Ya-Fei Tetrahedron Letters, 2014 , vol. 55, # 8 p. 1406 - 1411

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Citation Number: 7

Abstract

Abstract We reported an efficient ligand-free Co (OAc) 2· 4H 2 O/NaOH/O 2/ethylene glycol reaction system that enables selective aerobic oxidation of a wide range of substrates covering 2, 6-di-EWG-, 2, 3, 6-tri-EWG-, 2-EWG-, and 2-EWG-6-EDG-substituted 4-cresols into the corresponding 4-hydroxybenzaldehydes. Based on the experimental investigations and well-defined p-benzoquinone methides, a plausible reaction mechanism was ...