Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3, 4-Diaminopyridine prodrug design and characterization

…, I Kinoyama, MS Hixon, A Di Mola, D Globisch…

Index: Zakhari, Joseph S.; Kinoyama, Isao; Hixon, Mark S.; Di Mola, Antonia; Globisch, Daniel; Janda, Kim D. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6203 - 6209

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Citation Number: 14

Abstract

Botulism is a disease characterized by neuromuscular paralysis and is produced from botulinum neurotoxins (BoNTs) found within the Gram positive bacterium Clostridium botulinum. This bacteria produces the most deadliest toxin known, with lethal doses as low as 1ng/kg. Due to the relative ease of production and transport, the use of these agents as potential bioterrorist weapons has become of utmost concern. No small molecule ...