e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and antiarrhythmic properties of quaternary derivatives of 1-[α-naphthoxy]-2-hydroxy-3-dimethylaminopropane

LMM Stankyavichene, GI Puzanov…

Index: Stankyavichene, L. M. M.; Puzanov, G. I.; Stankyavichyus, A. P.; Gendenshtein, E. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 5 p. 341 - 344 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 5 p. 554 - 558

Full Text: HTML

Citation Number: 0

Abstract

As there is no data on the effect of the structure of substitutents on the nitrogen atom on the antiarrhythmic action of quaternary propranolol derivatives, we have prepared a number of quaternary propranolol analogs of general formula by alkylation of l-(~-naphthoxy)-2- hydroxy-3-dime t hylaminopropane.

1-(dimethylamino)-3-naphthalen-1-yloxypropan-2-ol Structure

1-(dimethylamin...

2-Chloro-N-(2,6-dimethylphenyl)acetamide Structure

2-Chloro-N-(2,6...

~80%

[2-(2,6-dimethylanilino)-2-oxoethyl]-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,chloride Structure

[2-(2,6-dimethy...

1-Naphthalenol Structure

~%

[2-(2,6-dimethylanilino)-2-oxoethyl]-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,chloride Structure

[2-(2,6-dimethy...

UNII:07FN14F351 Structure

UNII:07FN14F351

~%

[2-(2,6-dimethylanilino)-2-oxoethyl]-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,chloride Structure

[2-(2,6-dimethy...

1-(dimethylamino)-3-naphthalen-1-yloxypropan-2-ol Structure

1-(dimethylamin...

2,4′-dibromoacetophenone Structure

2,4′-dibromoace...

~95%

[2-(4-bromophenyl)-2-oxoethyl]-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,bromide Structure

[2-(4-bromophen...

1-Naphthalenol Structure

~%

[2-(4-bromophenyl)-2-oxoethyl]-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,bromide Structure

[2-(4-bromophen...

UNII:07FN14F351 Structure

UNII:07FN14F351

~%

[2-(4-bromophenyl)-2-oxoethyl]-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,bromide Structure

[2-(4-bromophen...

1-(dimethylamino)-3-naphthalen-1-yloxypropan-2-ol Structure

1-(dimethylamin...

4-Bromobenzyl bromide Structure

4-Bromobenzyl b...

~88%

(2-bromophenyl)methyl-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,bromide Structure

(2-bromophenyl)...

1-Naphthalenol Structure

~%

(2-bromophenyl)methyl-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,bromide Structure

(2-bromophenyl)...

UNII:07FN14F351 Structure

UNII:07FN14F351

~%

(2-bromophenyl)methyl-(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethylazanium,bromide Structure

(2-bromophenyl)...

1-(dimethylamino)-3-naphthalen-1-yloxypropan-2-ol Structure

1-(dimethylamin...

2-Chloro-N-(2,4,6-trimethyl-phenyl)-acetamide Structure

2-Chloro-N-(2,4...

~91%

(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethyl-[2-oxo-2-(2,4,6-trimethylanilino)ethyl]azanium,chloride Structure

(2-hydroxy-3-na...

1-Naphthalenol Structure

~%

(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethyl-[2-oxo-2-(2,4,6-trimethylanilino)ethyl]azanium,chloride Structure

(2-hydroxy-3-na...

UNII:07FN14F351 Structure

UNII:07FN14F351

~%

(2-hydroxy-3-naphthalen-1-yloxypropyl)-dimethyl-[2-oxo-2-(2,4,6-trimethylanilino)ethyl]azanium,chloride Structure

(2-hydroxy-3-na...

UNII:07FN14F351 Structure

UNII:07FN14F351

Dimethylamine Structure

~63%

1-(dimethylamino)-3-naphthalen-1-yloxypropan-2-ol Structure

1-(dimethylamin...

1-Naphthalenol Structure

~%

1-(dimethylamino)-3-naphthalen-1-yloxypropan-2-ol Structure

1-(dimethylamin...