The Journal of organic chemistry

Et2Zn-catalyzed intramolecular hydroamination of alkynyl sulfonamides and the related tandem cyclization/addition reaction

Y Yin, W Ma, Z Chai, G Zhao

Index: Yin, Yan; Ma, Wenying; Chai, Zhuo; Zhao, Gang Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5731 - 5736

Full Text: HTML

Citation Number: 114

Abstract

Intramolecular hydroamination of alkynyl amides was effected by a catalytic amount of Et2Zn (20 mol%) to form indole derivatives, and a tandem cyclization/nucleophilic addition procedure involving reaction of the indole zinc salt intermediate with acid chlorides or halides was developed to provide an efficient approach to C3-substituted indole derivatives when an excess of Et2Zn (120 mol%) was used.