Tetrahedron

An efficient synthesis of benzofurans and their application in the preparation of natural products of the genus Calea

M del Carmen Cruz, J Tamariz

Index: Del Carmen Cruz, Maria; Tamariz, Joaquin Tetrahedron, 2005 , vol. 61, # 42 p. 10061 - 10072

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Citation Number: 29

Abstract

The intramolecular cyclization of the β-substituted olefins methyl 2-aryloxy-3- dimethylaminopropenoates catalyzed by Lewis acids leads to a short and novel synthesis of benzofurans. When the olefins 4-dimethylamino-3-aryloxy-3-buten-2-ones were used, the cyclization process was faster and provided the corresponding substituted 2- acetylbenzofurans. Among the latter, naturally occurring compounds calebertin (), ...